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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524798Generated: October 31, 2026

HCID 20373768, compound → HCID 118107628, compound

https://huagongshe.com/reaction/524798

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 20373768HCID 20373768—
ReactantEthyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylateHCID 59495567—
ProductHCID 118107628HCID 11810762886.1%

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.51 g, 3 mmol) was reacted with 3-(morpholin-2-yl)propanamide (0.47 g, 3 mmol) according to the procedure as described in Example 25, Step B to give the title compound as a yellow solid (1.5 g, 86%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340538B2
Source datasetuspto-grants-2016_05
ORD IDord-2d2d4f2509dc4cb2827620bb49f34358
Source noteuspto-grants-2016_05