Phenethylamine → 9-Bromo-5-phenethylcarbamoyl-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione

Participants

Reaction Steps

A procedure similar to that described in Example 5 was carried out with 9-bromo-5-carboxy-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (300 mg, 0.92 mmol) and phenethylamine (121 mg, 1.0 mmol) to give 330 mg of the title compound(84%): mp>250° C.; 1H NMR (270 MHz, DMSO-d6) δ12.12 (s, 1H), 8.21 (t, 1H, J=5.6 Hz), 7.09~7.39 (m, 7H), 5.07 (m, 1H), 3.24~3.33 (m, 2H), 2.64~2.73 (m, 3H), 2.25~2.32 (m, 2H), 1.80~1.95 (m, 1H).

Provenance & Evidence