Ammonium Chloride → 5-Methoxythiazole-2-carboximidamide hydrochloride

HRID 524803Notes

Reaction equation

[CH3:1][O:2][C:3]1[S:7][C:6]([C:8]#[N:9])=[N:5][CH:4]=1.C[O-].[Na+].[Cl-:13].[NH4+:14]>>[ClH:13].[CH3:1][O:2][C:3]1[S:7][C:6]([C:8](=[NH:14])[NH2:9])=[N:5][CH:4]=1

Participants

Reactant 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 900443835-Methoxythiazole-2-carbonitrile

Product 1

HCID 900443915-Methoxythiazole-2-carboximidamide hydrochlorideYield 50.1%

Procedure

5-methoxythiazole-2-carbonitrile (0.74 g, 5.26 mmol) was reacted with sodium methoxide (0.28 g, 5.26 mmol) and ammonium chloride (0.6 g, 11 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (0.51 g, 50%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-0acb2cb2b6f34530ada9a9277acb8d23
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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