Ethyl Acetoacetate → Ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(5-(trifluoromethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

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Reaction Steps

5-(trifluoromethyl)thiazole-2-carboximidamide hydrochloride (0.93 g, 4 mmol) was reacted with 2-bromo-4-fluorobenzaldehyde (0.81 g, 4 mmol) and ethyl 3-oxobutanoate (0.55 g, 4.2 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (0.45 g, 23%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence