2-(Morpholin-2-yl)acetic acid hydrochloride → 2-(4-((6-(2-Chloro-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(pyrazin-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acetic acid

Participants

Reaction Steps

Ethyl 6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1 g, 2.2 mmol) was reacted with 2-(morpholin-2-yl)acetic acid hydrochloride (0.4 g, 2.2 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.36 g, 32%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence