HCID 63810060, compound → 4-(1H-Pyrazol-1-yl)-3-pyridinamine

HRID 524872Notes

Reaction equation

HRID 524872 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[N:10]1[CH:14]=[CH:13][CH:12]=[N:11]1)([O-])=O>CO.[Pd]>[N:10]1([C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[NH2:1])[CH:14]=[CH:13][CH:12]=[N:11]1

Participants

4

Reactant 1

HCID 63810060HCID 63810060, compound

Product 1

HCID 288900214-(1H-Pyrazol-1-yl)-3-pyridinamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 3-nitro-4-(1H-pyrazol-1-yl)pyridine (410 mg, 2.15 mmol) in MeOH (15 mL) was added Pd on C (10%, wet, Degussa) (129 mg) and the reaction mixture was vigorously stirred overnight at RT under an atmosphere of hydrogen (balloon). The catalyst was filtered off and the filtrate was concentrated under reduced pressure yielding 4-(1H-pyrazol-1-yl)pyridin-3-amine. (285 mg, 82%). MS (ES+) 161.1.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7d9eea4f3d7744f3bcde5f12db8af524
Source dataset
uspto-grants-2016_05
Patent number
US09340546B2

Reaction notes

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