Cyclohexylamine → 9-Bromo-5-cyclohexylcarbamoyl-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione

Participants

Reaction Steps

A procedure similar to that described in Example 5 was carried out with 9-bromo-5-carboxy-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (300 mg, 0.92 mmol) and cyclohexylamine (100 mg, 1.0 mmol) to give 340 mg of the title compound (91%): mp>270° C.; 1H NMR (270 MHz, DMSO-d6) δ12.14 (s, 1H), 8.03 (d, 1H, J=7.9 Hz), 7.16 (bs, 1H), 7.14 (bs, 1H), 5.08~5.13 (m, 1H), 3.42~3.59 (m, 1H), 2.79 (dm, 1H, J=16.8 Hz), 2.45~2.63 (m, 1H), 2.36 (dm, 1H, J=13.5 Hz), 1.85~2.02 (m, 1H), 1.63~1.74 (m, 4H), 1.05~1.33 (m, 6H).

Provenance & Evidence