HCID 86720992, compound → HCID 86720993, compound

HRID 524935Notes

Reaction equation

HRID 524935 reaction equation
[CH3:1][N:2]([CH3:20])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[N+:17]([O-])=O)=[CH:6][N:5]=1>CO.[Pd]>[CH3:20][N:2]([CH2:3][C:4]1[N:5]=[CH:6][C:7]([O:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[NH2:17])=[CH:8][CH:9]=1)[CH3:1]

Participants

4

Reactant 1

HCID 86720992HCID 86720992, compound

Product 1

HCID 86720993HCID 86720993, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

N,N-dimethyl-1-(5-((3-nitropyridin-4-yl)oxy)pyridin-2-yl)methanamine (150 mg, 0.5469 mmol), Pd/C (10%) (58.20 mg, 0.5469 mmol) in MeOH (15 mL) was stirred overnight at RT under hydrogen (balloon). The catalyst was filtered off and the filtrate was concentrated in vacuo to yield the title product as a clear oil. MS (ES+) 245.2.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-72108d0946b34514a881290a547c2c73
Source dataset
uspto-grants-2016_05
Patent number
US09340546B2

Reaction notes

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