1-((4-methoxyphenyl)methyl)-1H-pyrazol-4-amine → (S)-tert-Butyl 1-(3-bromo-2-(1-(4-methoxybenzyl)-1H-pyrazol-4-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

Participants

Reaction Steps

This compound was prepared starting from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (300 mg, 0.77 mmol) and 1-(4-methoxybenzyl)-1H-pyrazol-4-amine (469 mg, 2.31 mmol) following the experimental procedure described in Preparation 27a to afford 271 mg (96% purity, 60% yield) of the title compound after purification by flash chromatography (0% to 70% AcOEt/hexanes).

Provenance & Evidence