HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butoxycarbonylalanine → (S)-tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-imidazol-1-ylamino)propan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butoxycarbonylalanine | HCID 85082 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Amino-N-phenyl-1H-imidazole-2-carboxamide | HCID 21104352 | — |
| Product | (S)-tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-imidazol-1-ylamino)propan-2-ylcarbamate | HCID 86722020 | 73% |
Reaction Steps
The title compound was prepared following the experimental procedure described in preparation 20a, from 1.12 g (5.54 mmol) of 1-amino-N-phenyl-1H-imidazole-2-carboxamide, 1.26 g (6.65 mmol) of (S)-2-(tert-butoxycarbonylamino)propanoic acid and 1.03 g (6.65 mmol) of EDC.HCl. The solid obtained was triturated in diisopropylether to give 1.51 g (67% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340547B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-23d937da992b4672a5318439ccf0a56c |
| Source note | uspto-grants-2016_05 |