(S)-2-((tert)-Butoxycarbonyl)amino)butanoic acid → HCID 86722024, compound

Participants

Reaction Conditions

Reaction Steps

1.60 g (6.18 mmol) of 1-amino-N-(3,5-difluorophenyl)-1H-imidazole-2-carboxamide, 1.64 g (8.65 mmol) of (S)-2-(tert-butoxycarbonylamino)butanoic acid and 1.34 g (8.65 mmol) of EDCHCl were dissolved in 45 mL of THF and stirred at 55° C. overnight and at room temperature for 2 days. Then the solvent was evaporated and the crude residue was taken up in ethyl acetate and washed with brine. The organic layer was dried over magnesium sulphate, filtered and the solvent was evaporated. The solid obtained was redissolved in the minimum amount of ethyl acetate and diisopropylether was added until a solid precipitated, which was filtered to furnish 1.51 g (57% yield) of the title compound.

Provenance & Evidence