HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → tert-Butyl (2S)-1-(3-bromo-2-(tetrahydro-2H-pyran-3-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Oxan-3-amine | HCID 5200320 | — |
| Edukt | (S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate | HCID 86722018 | — |
| Produkt | tert-Butyl (2S)-1-(3-bromo-2-(tetrahydro-2H-pyran-3-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722031 | — |
Reaktionsschritte
Same procedure as described in preparation 137a was used from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (4.00 g, 10.25 mmols) and tetrahydro-2H-pyran-3-amine.HCl (2.12 g, 15.41 mmols). The title compound was obtained (2.24 g, 48%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09340547B2 |
| Quelldatensatz | uspto-grants-2016_05 |
| ORD ID | ord-52f7600c7e394685a44a0e1f1d0d7335 |
| Quellennotiz | uspto-grants-2016_05 |