(S)-2-((tert)-Butoxycarbonyl)amino)butanoic acid → HCID 86722037, compound

HRID 525017Notes

Reaction equation

HRID 525017 reaction equation
[NH2:1][N:2]1[CH:6]=[CH:5][C:4]([Br:7])=[C:3]1[C:8]([NH:10][C:11]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=1)=[O:9].[C:19]([O:23][C:24]([NH:26][C@@H:27]([CH2:31][CH3:32])[C:28](O)=[O:29])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[Br:7][C:4]1[CH:5]=[CH:6][N:2]([NH:1][C:28](=[O:29])[C@@H:27]([NH:26][C:24](=[O:25])[O:23][C:19]([CH3:21])([CH3:20])[CH3:22])[CH2:31][CH3:32])[C:3]=1[C:8](=[O:9])[NH:10][C:11]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=1

Participants

3

Reactant 2

HCID 2755934(S)-2-((tert)-Butoxycarbonyl)amino)butanoic acidHCID 70978853HCID 70978853, compound

Product 1

HCID 86722037HCID 86722037, compoundYield 14%

Procedure

The title compound was prepared from 1-amino-3-bromo-N-(3,5-difluorophenyl)-1H-pyrrole-2-carboxamide (1 g, 3.16 mmol) and (S)-2-(tert-butoxycarbonylamino)butanoic acid following the experimental procedure described in Preparation 45a. 0.26 g (14% yield) of the desired compound were obtained.

Sources & evidence

ORD record
ord-36ea2ce028084a50a3433d6280c5648f
Source dataset
uspto-grants-2016_05
Patent number
US09340547B2

Reaction notes

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