1-Phenethylamine, (-)- → HCID 86592245, compound

HRID 525024Notes

Reaction equation

HRID 525024 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8]C)=O.[C:10]1([C@@H:16]([NH2:18])[CH3:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([C@@H:16]([NH:18][C:6]([C:2]2[NH:1][CH:5]=[CH:4][CH:3]=2)=[O:8])[CH3:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 758181-Phenethylamine, (-)-HCID 136930Methyl pyrrole-2-carboxylate

Product 1

HCID 86592245HCID 86592245, compoundYield 80.9%

Procedure

The title compound was prepared from methyl 1H-pyrrole-2-carboxylate (8.0 g, 0.06 mol) and (S)-1-phenylethanamine (24.7 ml, 0.19 mol) following the experimental procedure described in Preparation 44a. 10.4 g (75% yield) of the desired compound were obtained.

Sources & evidence

ORD record
ord-a8fef2eac739459892df5cdb312c9350
Source dataset
uspto-grants-2016_05
Patent number
US09340547B2

Reaction notes

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