HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidin-5-amine → (S)-Benzyl 1-(3-bromo-2-(pyrimidin-5-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidin-5-amine | HCID 344373 | — |
| Reactant | (S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate | HCID 86722049 | — |
| Product | (S)-Benzyl 1-(3-bromo-2-(pyrimidin-5-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722051 | 62.3% |
Reaction Steps
The title compound was prepared from (S)-methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-bromo-1H-pyrrole-2-carboxylate (0.81 g, 1.91 mmol) and pyrimidin-5-amine (1.45 g, 15.3 mmol) following the experimental procedure described in Preparation 44a. 0.58 g (62% yield) of the desired compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340547B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-637bc35940f1483fa25b529fd4e47e68 |
| Source note | uspto-grants-2016_05 |