HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine → (S)-tert-Butyl 4-(benzyloxy)-1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)butan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine | HCID 15058464 | — |
| Reactant | 1-amino-N-phenyl-1H-pyrrole-2-carboxamide | HCID 70922454 | — |
| Product | (S)-tert-Butyl 4-(benzyloxy)-1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)butan-2-ylcarbamate | HCID 86722052 | 99.6% |
Reaction Steps
The title compound was prepared from 1-amino-N-phenyl-1H-pyrrole-2-carboxamide (0.65 g, 3.2 mmol) and (S)-4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanoic acid (1.0 g, 3.2 mmol) following the experimental procedure described in Preparation 73a. 1.57 g (96% yield) of the desired compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340547B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-46b1e72f7fd44e81986c33a8b9028987 |
| Source note | uspto-grants-2016_05 |