1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid → HCID 86722054, compound

HRID 525035Notes

Reaction equation

HRID 525035 reaction equation
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:8].[C:16]([O:20][C:21]([NH:23][C:24]1([C:27](O)=[O:28])[CH2:26][CH2:25]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:10]1([NH:9][C:7]([C:3]2[N:2]([NH:1][C:27]([C:24]3([NH:23][C:21](=[O:22])[O:20][C:16]([CH3:18])([CH3:17])[CH3:19])[CH2:26][CH2:25]3)=[O:28])[CH:6]=[CH:5][CH:4]=2)=[O:8])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 6883961-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acidHCID 709224541-amino-N-phenyl-1H-pyrrole-2-carboxamide

Product 1

HCID 86722054HCID 86722054, compoundYield 95.4%

Procedure

The title compound was prepared from 1-amino-N-phenyl-1H-pyrrole-2-carboxamide (0.30 g, 1.5 mmol) and 1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid (0.30 g, 1.5 mmol) following the experimental procedure described in Preparation 73a. 0.55 g (91% yield) of the desired compound were obtained.

Sources & evidence

ORD record
ord-03bd36e55f4545309fbe97f09d97878b
Source dataset
uspto-grants-2016_05
Patent number
US09340547B2

Reaction notes

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