HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isoxazolamine → (S)-tert-Butyl 1-(2-(isoxazol-3-yl carbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isoxazolamine | HCID 1810216 | — |
| Reactant | (S)-methyl 1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate | HCID 86722033 | — |
| Product | (S)-tert-Butyl 1-(2-(isoxazol-3-yl carbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722059 | — |
Reaction Steps
Same procedure as described in preparation 133a was used from (S)-methyl 1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (854 mg, 2.17 mmols) and isoxazol-3-amine (0.48 ml, 6.50 mmols). The title compound was obtained (919 mg, 55% purity, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340547B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-0281437703964958a4469deec4914efb |
| Source note | uspto-grants-2016_05 |