1-((4-methoxyphenyl)methyl)-1H-pyrazol-4-amine → (S)-tert-Butyl 1-(2-(1-(4-methoxybenzyl)-1H-pyrazol-4-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

Participants

Reaction Steps

This compound was prepared starting from (S)-methyl 1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (900 mg, 2.89 mmol) and 1-(4-methoxybenzyl)-1H-pyrazol-4-amine (1.24 g, 6.10 mmol) following the experimental procedure described in Preparation 27a to afford 1.02 g (100% purity, 73% yield) of the title compound after purification by flash chromatography (0% to 100% AcOEt/hexanes).

Provenance & Evidence