Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl 2-amino-4,5-dimethyl3-thenoate | HCID 78536 | — |
| Product | HCID 178435036 | HCID 178435036 | 85% |
Reaction Steps
The mixture of ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate (30 g, 0.15 mol) in 150 mL of formamide was heated at 180° C. for 4 h and cooled down. The mixture was poured into 200 mL of water and filtered. The solid was collected and recrystallized from ethanol to afford 5,6-dimethylthieno[2,3-d]pyrimidin-4-ol as yellow solid (23 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09340554B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-9c4354c443af405e9a8ec097e9633571 |
|---|
| Source note | uspto-grants-2016_05 |
|---|
