Ethyl Acetate → HCID 12859206, compound

Participants

Reaction Steps

To a solution of 2-phenylpropane-1,2-diol (300 mg, 1.972 mmol) in DCM (60 mL) was added Dess-Martin periodinane (836 mg, 1.972 mmol) at 0° C. The reaction mixture was then stirred for 2 hours at room temperature. After completion of reaction (monitored by TLC (TLC eluent: 50% EtOAc in petroleum ether, UV active)), the reaction mixture was quenched with saturated NaHCO3 solution and extracted with EtOAc. The combined organic layers were washed with water, saturated NaCl solution and dried over anhydrous Na2SO4. The solvents were removed under reduced pressure providing 2-hydroxy-2-phenylpropanal (250 g) as a colorless liquid, which was used without further purification.

Provenance & Evidence