Aniline → HCID 54313479, compound

Participants

Reaction Steps

A procedure similar to that described in Example 52 was carried out with 9-bromo-5-(1-carboxyethyl)-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (less polar) (100 mg, 0.28 mmol) and aniline (28 μL, 0.31 mmol) to give 70 mg of the title compound (58%): mp>300° C.; 1H NMR (270 MHz, DMSO-d6) δ12.07 (s, 1H), 10.00 (s, 1H), 7.52 (d, 2H, J=8 Hz), 7.29 (t, 1H, J=8 Hz), 7.19 (s, 1H), 7.17 (s, 1H), 7.05 (t, 1H, J=8 Hz), 5.19 (bd, 1H, J=9 Hz), 3.10 (ddd, 1H, J=17.1, 13.5, 4.5 Hz), 2.67~2.84 (m, 2H, J=17.1 Hz), 2.01 (dm, 1H, J=13.5 Hz), 1.72~1.92 (m, 1H), 1.02 (d, 3H, J=7 Hz).

Provenance & Evidence