反应详情

温度

0 °C

To a cooled (0° C.) THF (25 ml) solution of ethyl 5-(4-((4S,5R)-3-(tert-butoxycarbonyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-5-yl)phenyl)isoxazole-3-carboxylate (1.0 g, 2.2 mmol) is added sodium borohydride (0.25 g, 6.7 mmol) followed by methanol (3 ml added slowly). The reaction is stirred for 30 minutes at 0° C. and for one hour at room temperature. The excess sodium borohydride is quenched by the addition of saturated aqueous ammonium chloride (5 ml). The reaction mixture is diluted with ethyl acetate (50 ml) and water (25 ml). The layers were mixed and allowed to separate. The organic phase is collected, dried over sodium sulfate and concentrated to give the product, (4S,5R)-tert-butyl 4-(fluoromethyl)-5-(4-(3-(hydroxymethyl)isoxazol-5-yl)phenyl)-2,2-dimethyl-oxazolidine-3-carboxylate (875 mg, 96%), as a viscous oil. 1H NMR (400 MHz, CDCl3) 1.52 (s, 9 H) 1.59 (s, 3 H) 1.74 (br. s., 3 H) 2.03-2.08 (m, 1 H) 3.83-3.96 (m, 1 H) 4.40-4.60 (m, 2 H) 4.85 (d, J=6.06 Hz, 2 H) 5.19 (d, J=7.58 Hz, 1 H) 6.63 (s, 1 H) 7.57 (d, J=8.34 Hz, 2 H) 7.82 (d, J=8.34 Hz, 2 H); m/z (Cl) 407 ([M+H]+.

1. additionadded slowly)
2. customThe excess sodium borohydride is quenched by the addition of saturated aqueous ammonium chloride (5 ml)
3. additionThe reaction mixture is diluted with ethyl acetate (50 ml) and water (25 ml)
4. additionThe layers were mixed
5. customto separate
6. customThe organic phase is collected
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated