HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide | HCID 72546089 | — |
| Product | 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide | HCID 89906702 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 22.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 22.2) and 2-methylamino-ethanol to afford a white crystalline solid. HPLC (Condition 4) tR=5.72 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=452.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340537B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-89a2ad1b89894c47a8f025bc1e7fbe42 |
| Source note | uspto-grants-2016_05 |