HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-cyano-1-methyl-1H-pyrrol-2-yl)boronic acid → HCID 118044955, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-cyano-1-methyl-1H-pyrrol-2-yl)boronic acid | HCID 11708078 | — |
| Reactant | (R)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide | HCID 72545856 | — |
| Product | HCID 118044955 | HCID 118044955 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 32.1 using (R)-5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 22.1) and 5-cyano-1-methyl-1H-pyrrol-2-ylboronic acid to afford an off-white powder. HPLC (Condition 4) tR=5.96 min, UPLC-MS (Condition 3) tR=1.11 min, m/z=486 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340537B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-3ab6c7d6d9a842f6b1a637112d508ebe |
| Source note | uspto-grants-2016_05 |