HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamic acid, 3-azabicyclo[3.1.0]hex-1-YL-, 1,1-dimethylethyl ester → 6-(1-Amino-3-azabicyclo[3.1.0]hexan-3-yl)-N-(4-(chlorodifluoromethoxy)phenyl)-5-(1H-pyrazol-5-yl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamic acid, 3-azabicyclo[3.1.0]hex-1-YL-, 1,1-dimethylethyl ester | HCID 21256582 | — |
| Reactant | 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)nicotinamide | HCID 86702637 | — |
| Product | 6-(1-Amino-3-azabicyclo[3.1.0]hexan-3-yl)-N-(4-(chlorodifluoromethoxy)phenyl)-5-(1H-pyrazol-5-yl)nicotinamide | HCID 118044762 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Example 33 using 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)nicotinamide (Stage 48.2) and tert-butyl 3-azabicyclo[3.1.0]hexan-1-ylcarbamate to afford an off-white foam. HPLC (Condition 4) tR=4.32 min, UPLC-MS (Condition 3) tR=0.79 min, m/z=461.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340537B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e4bcf612d77c415a8d60de9beb716376 |
| Source note | uspto-grants-2016_05 |