Trifluoroacetic acid → HCID 118045003, compound

Participants

Reaction Steps

TFA (0.288 mL, 3.74 mmol) was added to a solution of tert-butyl ((1-(5-((4-(chlorodifluoromethoxy)phenyl)carbamoyl)-3-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)pyridin-2-yl)-3-hydroxypyrrolidin-3-yl)methyl)carbamate (Stage 83.1, 74 mg, 0.112 mmol) in DCM (0.6 mL) and the RM was stirred at RT for 4 h. The solvent was evaporated off under reduced pressure and the crude product was purified by preparative HPLC. The fractions containing pure product were combined, the TFA was removed using a PL HCO3-MP cartridge and the solvent was evaporated off under reduced pressure to afford the title compound as a beige solid. UPLC-MS (Condition 8) tR=0.78 min, m/z=479.3 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.64-1.87 (m, 2H) 2.59 (s, 2H) 3.07 (s, 1H) 3.16-3.48 (m, 3H) 4.74 (br. s, 1H) 6.39 (d, J=1.83 Hz, 1H) 7.34 (d, J=8.93 Hz, 2H) 7.67-7.88 (m, 1H) 7.90 (s, 2H) 8.04 (d, J=2.32 Hz, 1H) 8.74 (s, 1H) 10.20 (s, 1H) 12.93 (br. s, 1H).

Provenance & Evidence