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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 525769Generated: October 31, 2026

3-methylazetidin-3-ol Hydrochloride → N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxy-3-methylazetidin-1-yl)-5-iodonicotinamide

https://huagongshe.com/reaction/525769

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-methylazetidin-3-ol HydrochlorideHCID 11542781—
Reactant6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamideHCID 86702626—
ProductN-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxy-3-methylazetidin-1-yl)-5-iodonicotinamideHCID 89906632—

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Stage 88.1 using 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide (Stage 48.3) and 3-methylazetidine-3-ol hydrochloride to afford a beige foam. HPLC (Condition 7) tR=6.84 min, UPLC-MS (Condition 8) tR=1.14 min, m/z=510.0/512.0 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340537B2
Source datasetuspto-grants-2016_05
ORD IDord-9e6d69ffb668452fb12e999deb4b1dad
Source noteuspto-grants-2016_05