HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(benzyloxy)-N-(2-fluoro-5-methylphenyl)benzamide → N-(2-fluoro-5-methylphenyl)-3-hydroxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(benzyloxy)-N-(2-fluoro-5-methylphenyl)benzamide | HCID 42967757 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(2-fluoro-5-methylphenyl)-3-hydroxybenzamide | HCID 28879615 | — |
Reaction Steps
A solution of 3-(benzyloxy)-N-(2-fluoro-5-methylphenyl)benzamide (1.5 g, 4.48 mmol from Step 1) in 20 ml of MeOH containing 10% Pd/C (150 mg) was stirred under a hydrogen balloon at room temperature for 2 hours. The catalyst was removed by filtration. The filtrate solution was evaporated to dryness under reduced pressure to give N-(2-fluoro-5-methylphenyl)-3-hydroxybenzamide as light-beige solid. Yield: 1.1 g, 100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340555B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-0e96694e2b3c4e85b807c9d11e6357a3 |
| Source note | uspto-grants-2016_05 |