HCID 86732758, compound → HCID 86732759, compound

Participants

Reaction Conditions

Reaction Steps

To a yellow solution of 1-ethyl-8-fluoro-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one (10 g, 20.26 mmol) in Dichloromethane (DCM) (100 mL) was added manganese dioxide (17.62 g, 203 mmol), and the mixture was stirred at 25° C. for 6.5 h. LCMS indicated completion of the reaction. The solid was filtered off through Celite and washed with DCM, the filtrate was concentrated to afford 1-ethyl-8-fluoro-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carbaldehyde (6.5 g, 13.22 mmol, 65.3% yield) as a yellow solid that was used in the next step without further purification. LCMS (M+H)+: 492.2.

Provenance & Evidence