Water → HCID 12873132, compound

Participants

Reaction Steps

A solution of 7-carboxy-5-ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-9-diazonium chloride (7.5 g, 23.17 mmol) (Mixture of 16c and 16d) in 50% H2SO4 (60 mL) was heated at 95° C. for 4 h. The reaction mixture was cooled down to r.t. and then poured into 450 mL of water. The precipitates were collected by filtration and dried to afford 5-chloro-1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (6 g, 18.61 mmol, 80% yield) as a yellow brown solid. LCMS: (M+H)+: 284.1.

Provenance & Evidence