HCID 86732765, compound → HCID 86732766, compound

Participants

Reaction Steps

To a yellow solution of 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy) quinolin-4(1H)-one (19 g, 30.9 mmol) in Dichloromethane (DCM) (250 mL) was added manganese dioxide (41.1 g, 402 mmol), and the mixture was stirred at r.t. for overnight. The mixture was then filtered through Celite and washed with DCM. The filtrate was concentrated to afford 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carbaldehyde (17 g, 27.4 mmol, 89% yield) as a yellow solid, which was used in the next step without further purification. LCMS: (M+H)+: 508.1.

Provenance & Evidence