HCID 86732798, compound → HCID 86732797, compound

Participants

Reaction Steps

To a yellow solution of 5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)cinnolin-4(1H)-one (6 g, 8.45 mmol) in Dichloromethane (DCM) (100 mL) was added manganese dioxide (12.11 g, 118 mmol), and the mixture was stirred at r.t. overnight. Solid was filtered off and washed with DCM. The filtrate was concentrated to afford 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydrocinnoline-3-carbaldehyde (4 g, 4.79 mmol, 56.7% yield) as a crude dark brown solid. LCMS: (M+H)+: 509.3.

Provenance & Evidence