HCID 86732807, compound → HCID 86732808, compound

Participants

Reaction Steps

To a yellow solution of 1-ethyl-5-fluoro-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy) quinolin-4(1H)-one (11 g, 22.29 mmol) in Dichloromethane (DCM) (100 mL) was added manganese dioxide (19.38 g, 223 mmol). The mixture was stirred at rt for 6.5 h. The mixture was then filtered through Celite and washed with DCM, the filtrate was concentrated to afford 1-ethyl-5-fluoro-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carbaldehyde (9.8 g, 19.94 mmol, 89% yield) as a yellow solid, which was used in the next step without further purification. LCMS: (M+H)+: 492.2.

Provenance & Evidence