Diethyl (ethoxymethylene)malonate → 1,3-Diethyl 2-[[(2,3-dimethoxyphenyl)amino]methylene]propanedioate

関与物質

反応条件

反応手順

To a mixture of 2,3-dimethoxyaniline (20 g, 131 mmol) in Ethanol (50 mL) was added diethyl 2-(ethoxymethylene)malonate (26.2 mL, 131 mmol). The mixture was heated at 80° C. for 1 h. LCMS indicated completion of the reaction. The mixture was concentrated in vacuo to remove ethanol, and washed with hexane to afford diethyl 2-(((2,3-dimethoxyphenyl)amino)methylene)malonate (38 g, 118 mmol, 90% yield) as a white solid. This crude mixture was directly used in next step. LCMS: (M+H)+: 324.2.

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