HCID 86732818, compound → HCID 86732820, compound

Participants

Reaction Steps

To a yellow solution of 1-ethyl-3-(hydroxymethyl)-7,8-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one (16 g, 33.6 mmol) in Dichloromethane (DCM) (200 mL) was added manganese dioxide (29.3 g, 336 mmol), and the mixture was stirred at rt for 6.5 h. The mixture was filtered through Celite and washed with DCM, the filtrate was concentrated to afford 1-ethyl-7,8-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinoline-3-carbaldehyde (10 g, 21.12 mmol, 62.8% yield) as a brown solid, which was used in the next step without further purification. LCMS: (M+H)+: 474.3.

Provenance & Evidence