Hydrochloric Acid → 6-Amino-2,3-dimethoxybenzoic acid hydrochloride

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Reaction Steps

6-((tert-Butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid (39 g, 131 mmol) was treated with HCl in dioxane (4N, 300 mL, 1200 mmol) at r.t. and the mixture was stirred at r.t. for 3 h. LCMS indicated completion of the reaction. The solid was collected by filtration, washed with ethyl ether and dried to afford 6-amino-2,3-dimethoxybenzoic acid, Hydrochloride (28.5 g, 120 mmol, 91% yield) as a white solid. LCMS: (M+H)+: 198.2.

Provenance & Evidence