HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 137231655, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Ethoxybenzoic acid nitrile | HCID 141176 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Boc-D-Arg(NO2)-OH | HCID 7021876 | — |
| Reactant | HCID 18975845 | HCID 18975845 | — |
| Reactant | L-Ascorbic Acid | HCID 54670067 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 137231655 | HCID 137231655 | 77% |
Reaction Steps
Prepared analogously to Example 8a) from Boc-D-Arg-(NO2)-OH, 4-ethoxybenzenemethylamine-hydrochloride (mp.: 262°-264° C.; from 4-ethoxybenzonitrile by catalytic hydrogenation in the presence of palladium/animal charcoal and aqueous hydrochloric acid), triethylamine and TBTU in a yield of 77% of theory. IR (CH2Cl2): 1730 cm-1 (ester-C=O) 1675 cm-1 (amide C=O) 1510 cm-1 (amide II)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616620 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-e7044d2e21e443a88af663f3fb94999d |
| Source note | uspto-grants-1997_04 |