Acetic Anhydride → HCID 89444616, compound

Participants

Reaction Steps

To a suspension of methyl 4-[[5-[(Z)—N′-hydroxycarbamimidoyl]-2-pyridyl]amino]-4-oxo-butanoate (obtained as described in step 1, 0.15 g, 0.56 mmol, 1 equiv.) in dichloromethane (30 mL) was added acetic anhydride (1.98 mL, 20.3 mmol, 36 equiv.). The mixture was stirred for 5 days, before concentration under vacuum giving methyl 4-[[5-[(Z)—N′-acetoxycarbamimidoyl]-2-pyridyl]amino]-4-oxo-butanoate which is used in the next step without extra purification.

Provenance & Evidence