Trifluoroacetic acid → HCID 118275227, compound

Participants

Reaction Steps

tert-Butyl {[6-methyl-2-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]methyl}carbamate (274 mg, 0.46 mmol) was initially charged in dichloromethane (5.0 ml), trifluoroacetic acid (526 mg, 4.61 mmol) was added and the mixture was stirred at room temperature for 2 hours. The solvent was removed completely under reduced pressure, giving 210 mg (86% of theory) of 5-(aminomethyl)-1-ethyl-6-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide, which were directly reacted further. HPLC-MS: log P=1.94; mass (m/z): 460.1.

Provenance & Evidence