HCID 136381119, compound → HCID 178512853, compound

HRID 52602Notes

Reaction equation

HRID 52602 reaction equation
[NH2:1][C:2](=[N:37][N+]([O-])=O)[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][CH2:35][OH:36])=[CH:30][CH:29]=1)=[O:25])[NH:8][C:9](=[O:23])[CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>[Pd].C(O)(=O)C>[C:17]1([CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:9]([NH:8][C@@H:7]([C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([CH2:34][CH2:35][OH:36])=[CH:30][CH:29]=2)=[O:25])[CH2:6][CH2:5][CH2:4][NH:3][C:2](=[NH:1])[NH2:37])=[O:23])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 1

HCID 136381119HCID 136381119, compound

Product 1

HCID 178512853HCID 178512853, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

Prepared analogously to Example 1c) from (R)-N5 -[Amino(nitroimino)methyl]-N2 -(diphenylacetyl)-N-[[4-(2-hydroxyethyl)-phenyl]methyl]-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% aqueous acetic acid.

Sources & evidence

ORD record
ord-5f607f1c541e4f1db0b3f59196d5b0f7
Source dataset
uspto-grants-1997_04
Patent number
US05616620

Reaction notes

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