Acetic Acid → HCID 178476712, compound

HRID 52603Notes

Reaction equation

HRID 52603 reaction equation
[NH2:1][C:2](=[N:35][N+]([O-])=O)[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31](O)=[CH:30][CH:29]=1)=[O:25])[NH:8][C:9]([CH:11]1[C:23]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:17]2[C:12]1=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:10].[C:39]([OH:42])(=[O:41])[CH3:40]>[Pd]>[CH:13]1[C:12]2[CH:11]([C:9]([NH:8][C@@H:7]([C:24]([NH:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[OH:41])=[O:25])[CH2:6][CH2:5][CH2:4][NH:3][C:2](=[NH:35])[NH2:1])=[O:10])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17]=2[CH:16]=[CH:15][CH:14]=1.[C:39]([O-:42])(=[O:41])[CH3:40]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 136381120HCID 136381120, compound

Product 1

HCID 178476712HCID 178476712, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared analogously to Example 1c) from (R)-N5 -[amino(nitroimino)methyl]-N2 -[(9-fluorenyl)carbonyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% aqueous acetic acid in a yield of 40% of theory.

Sources & evidence

ORD record
ord-6b6387301fcd42e2bb47ce5265d90503
Source dataset
uspto-grants-1997_04
Patent number
US05616620

Reaction notes

Loading…