HRID52603

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：NC(=N[N+](=O)[O-])NCCC[C@@H](NC(=O)C1c2ccccc2-c2ccccc21)C(=O)NCc1ccc(O)cc1

HCID136381120

未命名化合物

PRODUCTS

生成物

结构：CC(=O)[O-].N=C(N)NCCC[C@@H](NC(=O)C1c2ccccc2-c2ccccc21)C(=O)NCc1ccccc1O

HCID178476712

未命名化合物

收率 40%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

Prepared analogously to Example 1c) from (R)-N5 -[amino(nitroimino)methyl]-N2 -[(9-fluorenyl)carbonyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% aqueous acetic acid in a yield of 40% of theory.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6b6387301fcd42e2bb47ce5265d90503
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05616620
来源说明: uspto-grants-1997_04

反应 SMILES

[NH2:1][C:2](=[N:35][N+]([O-])=O)[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31](O)=[CH:30][CH:29]=1)=[O:25])[NH:8][C:9]([CH:11]1[C:23]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:17]2[C:12]1=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:10].[C:39]([OH:42])(=[O:41])[CH3:40]>[Pd]>[CH:13]1[C:12]2[CH:11]([C:9]([NH:8][C@@H:7]([C:24]([NH:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[OH:41])=[O:25])[CH2:6][CH2:5][CH2:4][NH:3][C:2](=[NH:35])[NH2:1])=[O:10])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17]=2[CH:16]=[CH:15][CH:14]=1.[C:39]([O-:42])(=[O:41])[CH3:40]