反应详情

温度

100 °C

The compound (12.9 mmol) obtained in Step 3 was dissolved in 2-butanol (70 mL), and 4-(4-methylpiperazin-1-yl)benzeneamine (12.9 mmol) and trifluoroacetic acid (12.9 mmol) were added thereto. The mixture was stirred at 100° C. for 16 hours to complete the reaction, diluted with dichloromethane, and then washed with sat. NaHCO3 aqueous solution. The organic layer was dried with anhydrous sodium sulfate and then filtered and distilled under a reduced pressure. The residue was separated by column chromatography (dichloromethane:methanol=20:1 (volume ratio)) to obtain the title compound (yield: 42%).

1. customthe reaction
2. washwashed with sat. NaHCO3 aqueous solution
3. dry with materialThe organic layer was dried with anhydrous sodium sulfate
4. filtrationfiltered
5. distillationdistilled under a reduced pressure
6. customThe residue was separated by column chromatography (dichloromethane:methanol=20:1 (volume ratio))