HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4,6-Dichloro-1,5-naphthyridin-3-yl)propan-1-one → 1-(6-Chloro-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4,6-Dichloro-1,5-naphthyridin-3-yl)propan-1-one | HCID 89705642 | — |
| Reactant | HCID 178483674 | HCID 178483674 | — |
| Product | 1-(6-Chloro-4-((4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)propan-1-one | HCID 117773991 | 93.4% |
Reaction Steps
Following general procedure I, 1-(4,6-dichloro-1,5-naphthyridin-3-yl)propan-1-one (255 mg, 1.0 mmol) was reacted with trans-4-((dimethylamino)methyl)cyclohexanamine (310 mg, 2.0 mmol) to afford the product (350 mg, 93%) as a white solid: ESI MS m/z 375 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09345709B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-d05e6ad2a69f49e089d168188b3edc1f |
| Source note | uspto-grants-2016_05 |