HCID 68281405, compound → HCID 86702754, compound

Participants

Reaction Steps

Methyl (S)-2-[(2S,3S)-2-((3S,4S)-3-benzyloxycarbonylamino-4-tertbutoxycarbonylamino-5-phenylpentanoylamino)-3-methylpentanoylamino]-3-methylbutanoate (2.76 g; 4.04 mmol) were dissolved in 10 ml of HCl solution in dioxane (4 M) in a flask, and the mixture was stirred at RT for 5 h. Excess HCl was removed using the house vacuum, the solvent was removed in vacuo, and the residue was lyophilised overnight, giving 2.4 g of methyl (S)-2-[(2S,3S)-2-((3S,4S)-4-amino-3-benzyloxycarbonylamino-5-phenylpentanoylamino)-3-methylpentanoylamino]-3-methylbutyrate as a white solid. (Yield 92.2%, content 94%). MS-FAB (M+H+)=569.3 Rf (polar method): 1.67 min.

Provenance & Evidence