Hydroxyamine hydrochloride → HCID 71565457, compound

Participants

Reaction Steps

To a solution of methyl 4-((2-methyl-1,2,3,4-tetrahydropyrimido[1,6-a]indol-5-yl)thio)benzoate (0.4 g) and NH2OH.HCl (0.63 g) in 4 mL of dry MeOH was added 2.5 mL of 25% NaOMe solution in methanol. The reaction mixture was stirred for 4 h at r.t. and then quenched with 10 mL of potassium phosphate buffer solution. The mixture was extracted 40 mL of EtOAc. The extract was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel chromatography eluted with up to 10% MeOH/CH2Cl2 to give 0.12 g of the title product as white solid.

Provenance & Evidence