Water → HCID 89601845, compound

Participants

Reaction Steps

To a solution of 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (3.7 g) in 40 mL of CHCl3 cooled at 0° C. was added 4 g of NBS in two portions. After stirring for 2 h at r.t., the reaction mixture was treated with 30 mL of water and 20 mL of saturated aqueous solution of NaHCO3, and then extracted with 200 mL of CH2Cl2. The extract was dried over Na2SO4 for 2 days, and then filtered through a pad of silica gel, concentrated to give 4 g of the title compound as a light brown solid.

Provenance & Evidence