Trifluoroacetic acid → HCID 89601857, compound

Participants

Reaction Steps

To a solution of methyl 4-(hydroxy(2-methyl-1,2,3,4-tetrahydropyrimido[1,6-a]indol-5-yl)methyl)benzoate (80 mg) and Et3SiH (0.5 mL) in 5 mL of CH2Cl2 was added 0.1 mL of TFA. After stirring for 10 min at r.t., the reaction mixture was poured into 15 mL of saturated aqueous solution of NaHCO3 and the mixture was extracted with 2×20 mL of EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated. The residue was purified by silica gel chromatography eluted with up to 100% EtOAc/hexanes to give 70 mg of the title product as white solid.

Provenance & Evidence