Sodium Hydroxide → HCID 89601990, compound

Participants

Reaction Steps

To a solution of methyl 4-(2-methyl-1,2,3,4-tetrahydropyrimido[1,6-a]indole-5-carbonyl)benzoate (80 mg) in 1 mL of MeOH, 2 mL of THF and 1 mL of water was added 0.2 mL of 2N NaOH. After stirring for 0.5 h, the reaction mixture was treated with 5 mL of pH7 potassium phosphate buffer, extracted with 4×20 mL of EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated to give the crude title compound which was used for the next step without further purification.

Provenance & Evidence