Potassium Phosphate, Tribasic → HCID 71585650, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2-methyl-1,2,3,4-tetrahydropyrimido[1,6-a]indole-5-carbonyl)benzoic acid (60 mg) in 4 mL of DMF was added 100 mg of carbonyldiimidazole (CDI). The reaction mixture was stirred at 40° C. for 1 h and then treated with 280 mg of NH2OH.HCl, followed by 0.6 mL of Et3N. After stirring for 20 min at r.t., 5 mL of pH7 potassium phosphate buffer and 10 mL of brine were added and reaction mixture was extracted with 3×20 mL of EtOAc. The combined extracts were dried over Na2SO4, filtered, and the residue was purified by silica gel chromatography eluted with up to 10% MeOH/CH2Cl2 to give 10 mg of the title product as white solid.

Provenance & Evidence